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Peter Leadlay studied Chemistry at the University of Oxford, gained his DPhil there in 1974, and carried out postdoctoral research at ETH Zürich. He joined the Department of Biochemistry in Cambridge in 1979, ultimately serving as Herchel Smith Professor of Biochemistry from 2006-2017. 

He co-discovered a novel paradigm for enzyme catalysis by asking the question of how medicines like erythromycin and penicillin arise in nature; and the interests of his research group embraced the chemistry, biochemistry, genetics, genomics and synthetic biology of microbial antibiotic biosynthesis.  He co-founded the spinout company Biotica Technology, to exploit the technology, now continued by Isomerase Therapeutics. 

He was elected FRS in 2000 and FRSC in 2005. He held a Prix Chaire Internationale de Recherche “Blaise Pascal”, Institut Pasteur Paris in 2003-2004; the Remsen award of the ACS (USA) 2007; the Smets Prize Chair, Universities of Leuven/Louvain-la-Neuve, Belgium in 2009; the Inhoffen Medal awarded by the Helmholtz Foundation (Germany); an International Research Prize of the Humboldt Foundation, hosted at TU Berlin 2011-2012; and has been an Honorary Professor at the University of Wuhan since 2011.